International Operations has begun the Genesis Project. It is a project to locate young people who are shown to be Gen-Active, meaning that they gained their powers from something called the Gen-Factor either through direct exposure or through hereditary genes. Generation 13 (or Gen 13 for short) is the latest batch of young people who quickly learn that International Operations motives are more sinister than they appear.Caitlin Fairchild, Roxy Spaulding, Percival Eddie Chang, and Sarah Rainmaker must now band together to escape I.O. and their evil plans.